The Enzo can accelerate to 60 mph (97 km/h) in 3.14 seconds^[10] and can reach 100 mph (160 km/h) in 6.6 seconds.^[6] The ¼ mile (~400 m) time is from 10.8 to 11.2 sec at well over 130 mph (210 km/h) and the top speed is around 355 kilometers per hour (221 mph).^[11] It is rated at 12 miles per US gallon (20 L/100 km; 14 mpg_-imp) in the city and 18 miles per US gallon (13 L/100 km; 22 mpg_-imp) on the highway.

Despite the Enzo's extraordinary performance and price, the Ferrari 430 Scuderia (an improved version of Ferrari's current mid-range production car) is capable of lapping the Ferrari test track just as quickly as the Enzo.^[12]

Evo magazine tested the Enzo on the famed Nordschleife Circuit and ran a 7:25.21 lap time